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45 - 47 The elevation of the enzymes N-acetyl--D-glucosaminidase (NAG) and alanine aminopeptidase (AAP), has been associated with renal tubular damage with occupational exposures to Cd between 3.7 and 6.3 mg Cd/g creatinine in urine 44 , 45 , 48 Liang et al

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End stage renal disease (ESRD) with loss of kidney function results in renal replacement therapy with the need for dialysis or renal transplantation [29]

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